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Microscopy and stains in histology
Immune sera, Antibodies
Markers and conjugates
Tissue preparation
Immuno-staining, other ligand detection
Selection of staining protocols
Specificity, control reactions
Reagents, solutions
Laboratory methods
Acronyms
References
Applied cell labeling  

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HomeCell-MarkerMicroscopy and stains in histology → Immunohistology: an introduction to selective cell labeling as an essential element in the study of structure-function relationships




Immunohistology: an introduction to selective cell labeling as an essential element in the study of structure-function relationships

Wolf D. Kuhlmann

Division of Radiooncology, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany



The progress of genomic technologies enables systematic analysis of biological samples at the molecular level. Although these techniques provide important insights into the living process, all the data regarding DNA sequence variations or RNA transcript levels of cells will only provide a partial picture. It can be expected that in many if not the majority of disease cases proteomics are necessary to complete the picture. This holds especially true for the diagnosis of complex diseases and improved risk stratifications, and biomarkers with high sensitivity and specificity are the key. Biomarkers are a class of biological molecules with characteristic features which can be measured and visualized. They have an outstanding role in the identification of normal and diseased states. Moreover, they can give informations whether a disease is just occurring or in progression, and, thus are parameters for diagnostics, prognosis and in the assessment of sequential events.

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